Hydroxychloroquine‐Associated Renal Phospholipidosis: A Forgotten Complication of a Common Drug

ABSTRACT

Hydroxychloroquine (HCQ) treatment in systemic lupus erythematosus can induce drug‐induced phospholipidosis mimicking Fabry disease. A 32‐year‐old woman with lupus nephritis developed podocyte “zebra bodies” on electron microscopy. Normal lyso‐Gb3 excluded Fabry disease, confirming HCQ toxicity. Discontinuation and immunosuppression yielded stable renal function and improved proteinuria.