Outline
DOI: 10.1039/d6tb02056a ISSN: 2050-750X
Hydrogel-based delivery of solanesol enhances Treg–astrocyte crosstalk and reduces scar formation following spinal cord injury
Shaosong Sun, Xinrui Fan, Qiangqiang Guo, Heng Gu, Jincheng Tang, Feng Cai, Wei Wang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Lingjun Wang, Kun Xi, Yong Gu, Liang ChenHydrogel-delivered SOL boosts Tregs and CCN3, shifting astrocytes to A2 and switching αvβ3 to αvβ5, which inhibits PTK2–PTEN but activates AMPK–NEDD4 to degrade PTEN.
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