DOI: 10.1039/d6bm01209d ISSN: 2047-4830
Hyaluronan hydrogels optimally support rhabdomyosarcoma patient-derived organoids that recapitulate gene expression profiles of individual patient tumors
Yunyun Wang, Aiswariya Vadivellu, Nathaniel S. H. Too, Samantha A. Gan, Megan R. E. Wong, Sheng Hui Tan, Kenneth T. E. Chang, Eliza L. S. Fong, Amos H. P. LohHyaluronan and RGD-based hydrogels optimally support ex vivo culture of patient-derived rhabdomyosarcoma cells as three-dimensional organoids, with gene expression profiles more similar to that of original tumors compared to other culture methods.