Human Papilloma Virus Genotyping in Women with Condyloma Acuminata: A Cross-sectional, Hospital-based Study
Eswari Loganathan, Athota Kavitha, Smitha S Prabhu, Vinay BhatiaAbstract
Background:
Condyloma acuminata (CA), caused by human papillomavirus (HPV), is a prevalent sexually transmitted disease. Multiple HPV genotypes are implicated in causation, with types 6 and 11 being the most frequently associated.
Aims:
To study the HPV genotype in women with CA with respect to high-risk (HR) and low-risk variants, and in human immunodeficiency virus (HIV) positive and negative hosts.
Methods:
This prospective, cross-sectional study was conducted at three centers, including Manipal, Bangalore, and Guntur, from February 2021 to March 2024 (CTRI 2020/02/023218). Adult females aged 18–65 years, attending respective Dermatology departments, who were clinically diagnosed as CA, with a positive acetowhitening test, were included. HPV genotyping was performed on tissue samples.
Results:
A total of 79 women were included in the study. A total of 10 HPV genotypes were found in the 79 cases, among which HPV-6 (70.89%) and HPV-11 (22.78%) were most prevalent. HPV-16 was the most common HR HPV. Infection with a single HPV genotype (
Limitations:
This study had a small sample size from three centers, and a very low incidence of HIV positivity, due to which meaningful comparison between HIV positive and HIV-negative groups was impractical.
Conclusion:
HPV-6 and HPV-11 are still the predominant genotypes causing CA in Indian women, the leading HR genotype being HPV-16. Single HPV infections were more common, particularly in younger women.