Hodgkin’s Lymphoma Presenting with Dysphagia: A Rare Clinical Manifestation

Lymphomas are hematopoietic cancers affecting lymphoid cells, classified into Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). This case report discusses a 39-year-old female with no comorbidities presenting with dysphagia and weight loss. Imaging showed a mass in the mediastinum compressing the esophagus, suggestive of enlarged lymph nodes. Endoscopic ultrasound (EUS)-guided biopsies confirmed classical HL and the patient responded well to chemotherapy (ABVD regimen). Sarcoidosis, lung cancers, TB, lymphomas, distant metastases, or mediastinal inflammatory lymph nodes are some of the common causes of mediastinal lesions resulting in dysphagia. While mediastinal lymphadenopathy is a recognized cause of dysphagia, lymphoma presenting in this manner is an atypical occurrence and often poses a significant diagnostic challenge. This case highlights the rarity of HL causing dysphagia due to mediastinal lymphadenopathy, the importance of clinical suspicion, and the value of EUS-guided biopsy in diagnosing HL.