Histopathological and Immunohistochemical Evaluation of Salivary Gland Tumors
Lateef Ahmed Wani, Huma Mehmood, Humaira Aslam, Nazia M. Walvir
A
BSTRACT
Objectives:
We aimed to study the histomorphological spectrum of various salivary gland tumors (SGT) and to analyze the utility of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) expression pattern on immunohistochemistry (IHC) in the diagnosis of various malignant SGT.
Materials and Methods:
A cross-sectional study over 2 years. Formalin fixed paraffin embedded tissue from all the 111 cases of SGT were stained with hematoxylin and eosin to study their histomorphology. IHC for CK7 and CK20 was performed on 25 malignant SGT.
Results:
Out of total of 111 cases of SGT, 86 (77.5%) were benign and 25 (22.5%) were malignant. Pleomorphic adenoma was the most common benign neoplasm with 58 (52.25%) of total number of cases, whereas adenoid cystic carcinoma with 9 (8%) cases was the most frequent malignant tumor. Out of the total malignant SGT, 21 (84%) cases showed CK7+/CK20−, 02 (8%) cases showed CK7+/CK20+ immunoprofile, and 02 (8%) cases showed CK7−/CK20− expression on IHC.
Conclusion:
The expression pattern of CK7 and CK20 in malignant SGT is valuable for diagnosis and can assist in the differential diagnosis of primary versus metastatic tumors affecting the salivary glands.