High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors
Elena Fortin, Beatrice Campi, Ele Ferrannini, Andrea Mari, Linda G. Mellbin, Anna Norhammar, Per Näsman, Lars Rydén, Alessandro Saba, Giulia Ferrannini- Advanced and Specialized Nursing
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
OBJECTIVE
To explore the associations among mannose, indexes of insulin resistance (IR) and secretion, and long-term cardiovascular outcomes.
RESEARCH DESIGN AND METHODS
Fasting mannose was assayed in 1,403 participants, one-half of which had a first myocardial infarction (MI) with either normal glucose tolerance (n = 1,045) or newly detected dysglycemia (i.e., impaired glucose tolerance or type 2 diabetes; n = 358). Regression models were used to explore mannose associations with surrogate indexes of IR/insulin secretion. Multivariate Cox models were used to investigate the independent association between high (higher quartile) versus low (lower three quartiles) mannose and major adverse cardiac events (MACE) (n = 163) during the 10-year follow-up.
RESULTS
Mannose was independently associated with IR indexes (all P ≤ 0.001). High versus low mannose was independently associated with MACE (hazard ratio 1.54, 95% CI 1.07–2.20) in the overall population.
CONCLUSIONS
Mannose might represent a new biomarker able to track early, potentially detrimental glucometabolic alterations independently of glycemic state.