DOI: 10.1039/d6ra05763b ISSN: 2046-2069
Heterocyclic chemistry meets wound care: novel p -methyl- m -trifluoromethyl-phenyl-substituted pyrrol-2-one derivatives with antimicrobial and antibiofilm
Ioana C. Marinas, Alina Nicolescu, Cristina M. Al-Matarneh, Rafaela Vrabie, Sergiu Shova, Mihaela Silion, Mădălina-Diana Gaboreanu, Miruna Stan, Mariana C. Chifiriuc, Mariana PintealaBiofilm-associated infections represent a major challenge in the treatment of antimicrobial-resistant pathogens, particularly in chronic and wound-related infections where bacterial adherence and persistence reduce therapeutic efficacy.