DOI: 10.1021/acs.joc.6c00932 ISSN: 0022-3263
Heptafluorobutyric Acid-Induced Cross-Dehydrogenative Coupling Reactions of 1,2,4-Triazines. Part 2: p-Coupling with Arylamines
Anastasia P. Potapova, Elisaveta M. Gurina, Igor A. Khalymbadzha, Anton N. Tsmokaluk, Ainur D. Sharapov, Vasiliy S. Gaviko, Alexander S. Novikov, Dmitry S. Kopchuk, Ramil F. FatykhovAbstract
A heptafluorobutyric acid-induced cross-dehydrogenative coupling reaction of arylamines with 1,2,4-triazines has been described. This metal-free protocol enables regioselective para-C–H hetarylation of diverse arylamines including well-known fluorophore scaffolds, such as triphenylamine, carbazole, and phenothiazine, with easily accessible 1,2,4-triazines under mild conditions. This approach has potential for drug development and material design.