Hepatic arterial infusion chemotherapy versus transarterial chemoembolization, potential conversion therapies for single huge hepatocellular carcinoma: a retrospective comparison study
Min Deng, Hao Cai, Benyi He, Renguo Guan, Carol Lee, Rongping Guo- General Medicine
- Surgery
Background:
The treatment efficacy of transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for huge single hepatocellular carcinoma (HCC) has not been fully documented. The aim of this study was to compare TACE and HAIC for patients with solitary nodular HCCs ≥10 cm without vascular invasion and metastasis.
Methods:
From July 2015 to June 2020, a total of 147 patients with single nodular HCC ≥10 cm without vascular invasion and metastasis receiving TACE (n=77) or HAIC (n=70) were retrospectively enrolled. The tumor response, overall survival (OS), and progression-free survival (PFS) were investigated and compared. The treatment outcome of 2 transarterial interventional therapies was explored.
Results:
The objective response rate and PFS were higher in patients who received HAIC than in those who received TACE (44.3% vs. 10.4% and 8.9 vs. 4.2 mo, respectively;
Conclusions:
HAIC has better potential than TACE to control local tumors for huge single HCC without vascular invasion and metastasis and thus may be the preferred conversion therapy for these tumors.