DOI: 10.1158/2643-3230.bcd-26-0257 ISSN: 2643-3230
Hattrick against Lymphoma with Trispecific CAR T Cells
Maximilian Merz, Efrat LuttwakSummary:
Vasu and colleagues report one of the first clinical evaluations of rapidly manufactured trispecific chimeric antigen receptor T cells targeting CD19, CD20, and CD22. The lymphoma efficacy signal and favorable observed safety profile support further investigation, whereas the correlative analyses suggest that baseline T-cell fitness and early post-infusion functional states may remain important determinants of outcome.
See related article by Vasu et al., p. XX .