Halogen-based Non-covalent Interactions in Supramolecular Self-assembly

Halogens play a key role in natural and synthetic systems due to their remarkable physicochemical properties, enabling their integration into organic and inorganic compounds and supporting a wide range of applications. In supramolecular chemistry, their potential is often underestimated and largely focused on halogen-bonding in the bulk state, leaving other halogen-based supramolecular effects untapped. This chapter aims to broaden the understanding of halogen effects in self-assembly by introducing and classifying less common halogen-based non-covalent interactions and examining their impact on self-assembly phenomena in solution. This perspective aims to position halogens and their derived non-covalent interactions as essential tools in the design of functional and adaptive supramolecular materials.