Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus
Jing Wang, Qian-Qian Zhou, Yu-Jie Du, Lei Zhang, Lin Cheng, Ya-Qin Zhang, Yi-Yuan Wang, Zhang-Wei Lu, Xue Jin, Yang-Guang Cao, Ya-Ting He, Li-Lan Zhang, Long Qian, Bao-Zhu LiObjectives
Systemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is not clear.
Methods
Gut microbiota profiling was performed using 16S rRNA gene sequencing of fecal samples, and functional prediction was conducted using PICRUSt. Plasma lipidomics was performed using LC–MS. Associations between differentially abundant microbial taxa and differential lipids were assessed using Spearman’s rank correlation.
Results
We found obvious abnormalities in lipid metabolism in SLE patients. Sphingolipid metabolism and glycerophospholipid metabolism were the most significantly dysregulated pathways in these patients. There is an obvious intestinal flora imbalance in SLE patients, the
Conclusion
Our findings illustrate the disruption of the gut microbiome and lipid group in SLE patients, which may facilitate the development of new SLE interventions.