DOI: 10.56367/oag-052-12867 ISSN: 2516-3817

GUIDE-AI: A European initiative to bring guideline-directed medical treatment into the age of AI

Laura Paulowski, Enea Parimbelli, Hamid Hosseini, Matthias Groeschel

GUIDE-AI: A European initiative to bring guideline-directed medical treatment into the age of AI

The GUIDE-AI initiative aims to develop AI-powered guideline navigators for healthcare professionals and patients, enabling access to evidence-based recommendations while ensuring clinical judgment and patient context remain central to care. Clinical practice guidelines exist to support healthcare professionals in evidence-based decision making. However, clinical practice documents are often long, published in formats not meant for AI-based decision support systems, and updated frequently. As AI-based decision support becomes more relevant, so too does healthcare professional autonomy and judgement in guiding patient care.

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