Growth Assessment in Children Under 12 Years With Moderate‐to‐Severe Atopic Dermatitis Included in the
PEDISTAD
Observational Registry
Amy S. Paller, Alan D. Irvine, Eulalia Baselga, Marlies de Graaf, Elaine C. Siegfried, Michael J. Cork, Michele Ramien, Lawrence F. Eichenfield, Bryan Adams, Rajan Gupta, Marius Ardeleanu, Annie Zhang ABSTRACT
Background/Objective
The multifactorial disease burden of moderate‐to‐severe atopic dermatitis (AD) may affect children's growth. We report height, weight, and body mass index (BMI) of children under 12 years old with moderate‐to‐severe AD in comparison to the general population.
Methods
This was a cross‐sectional analysis of enrollment data from PEDISTAD, a global real‐world observational study of pediatric patients < 12 years old with moderate‐to‐severe AD.
Results
Among the 1329 children with moderate‐to‐severe AD, 72% of male children 5 to < 12 years were below the 50th percentile for height, as were 53% of females in this age group. In contrast, the weight of children 5 to < 12 years was above the 50th percentile in 56% of males and 52% of females, resulting in above‐average BMI values. In the 0 to < 5 years old age groups, height and weight were above the 50th percentile for 59% and 50% of female children, and 52% and 42% of male children, respectively.
Conclusions
This real‐world observational study showed in children 5 to < 12 years old with moderate‐to‐severe AD that the average height was lower than the US 50th percentile, with a more pronounced reduction in male children. Additionally, higher weight and, as a result, higher BMI were observed in the children included in this analysis.
Trial Registration: ClinicalTrials.gov identifier: NCT03687359