DOI: 10.1039/d6ra08343a ISSN: 2046-2069
Greener and more sustainable access to 6,7-dimethoxy-2-aryl-4-aminoquinazolines via microwave-assisted chemo-selective synthesis in bio-renewable solvents
Rhushikesh C. Deokar, Thrilokraj R, Nutan Sharma, Dhananjay Satav, Markus Obkircher, Sadaf Jamal Gilani, Saikat Sinha, Ramesh B. DateerOverview of the MW-accelerated greener synthesis. Top: two-step sequential synthesis flow (step 1: SNAr at C-4 in GVL/DIPEA, MW, 80 °C; step 2: Suzuki–Miyaura at C-2 in EtOH–H 2 O/PdCl 2 (PPh 3 ) 2 , MW, 100 °C); Bottom: key greener chemistry metrics.