DOI: 10.1039/d6cc02623k ISSN: 1359-7345
Gene mutation screening using single-molecule force spectroscopy: a novel way of PCR-independent genetic testing
Aratrika Ghosal, Asmita Paul, Budhaditya Bhattacharya, Aritra Bhowmick, Poushali Roy, Jayita Biswas, Rupa MukhopadhyaySynergistic application of atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) and locked nucleic acid (LNA) capture probe could play a pivotal role in PCR-independent screening of genetic diseases like cancer.