GAPIT: genome association and prediction integrated tool
Alexander E. Lipka, Feng Tian, Qishan Wang, Jason Peiffer, Meng Li, Peter J. Bradbury, Michael A. Gore, Edward S. Buckler, Zhiwu Zhang- Computational Mathematics
- Computational Theory and Mathematics
- Computer Science Applications
- Molecular Biology
- Biochemistry
- Statistics and Probability
Abstract
Summary: Software programs that conduct genome-wide association studies and genomic prediction and selection need to use methodologies that maximize statistical power, provide high prediction accuracy and run in a computationally efficient manner. We developed an R package called Genome Association and Prediction Integrated Tool (GAPIT) that implements advanced statistical methods including the compressed mixed linear model (CMLM) and CMLM-based genomic prediction and selection. The GAPIT package can handle large datasets in excess of 10 000 individuals and 1 million single-nucleotide polymorphisms with minimal computational time, while providing user-friendly access and concise tables and graphs to interpret results.
Availability: http://www.maizegenetics.net/GAPIT.
Contact: zhiwu.zhang@cornell.edu
Supplementary Information: Supplementary data are available at Bioinformatics online.