DOI: 10.1039/d6np00046k ISSN: 0265-0568
From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis
Weijian Li, Shuman Guan, Mingwei Li, Huijing Wang, Fener ChenThis review surveys advances in the total synthesis of protoberberines (PBs) over the past 20 years. It covers chemical and enzymatic strategies and analyzes key cyclization methods, stereochemical challenges, and sustainable approaches.