Frequency and Risk Factors of Atypical Features in Pediatric Acute Post-Streptococcal Glomerulonephritis
Sukriti Baroi, Shireen Afroz, Tahmina Ferdaus, Farhana Yasmin, Sheikh Anisul Haque, Abu HasnatAbstract
Background:
Acute post-streptococcal glomerulonephritis (APSGN) remains a significant cause of pediatric nephritic syndrome in low-resource settings. Understanding atypical features and associated risk factors are crucial for timely diagnosis and effective management.
Objective:
The objective of the study was to identify the frequency and risk factors of atypical presentations in children diagnosed with APSGN.
Materials and Methods:
A cross-sectional observational study was conducted on 50 pediatric patients diagnosed with APSGN at a tertiary care hospital in Bangladesh. Data were collected using structured questionnaires and reviewed hospital records. Inclusion criteria were children aged 3–18 years with clinical and laboratory evidence of APSGN. Ethical approval was obtained from the Institutional Review Board (BICH-ERC-13/02/2019). Data were analyzed using Statistical Package for the Social Sciences version 22. Descriptive statistics, chi-square tests, and logistic regression were applied.
Results:
Of the 50 children, 34% exhibited atypical features. Major atypical presentations included prolonged edema, hypertension, gross hematuria, and elevated serum creatinine. Risk factors significantly associated with atypical presentations included delayed treatment (
Conclusion:
Atypical features in APSGN are not uncommon and can lead to delayed diagnosis. Recognizing clinical predictors such as infection history and treatment delay are essential, particularly in low-resource settings.