DOI: 10.1002/cbdv.202301166 ISSN:
Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells
Trinh Thi Thuy, Nguyen Thi Thu Hoa, Nguyen Thi Thuy Linh, Ba Thi Cham, Nguyen Thi Hoang Anh, Nguyen Tuan Hiep, Sabrina Adorisio, Domenico V Delfino, Ngo Anh Bang, Bui Huu Tai, Phan Van Kiem- Molecular Biology
- Molecular Medicine
- General Chemistry
- Biochemistry
- General Medicine
- Bioengineering
Gnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives (1‐8) including for new compounds (1‐4). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR spectra. Among the isolates, compounds 1‐3 showed moderate NO production inhibition in LPS‐activated RAW264.7 cells with the IC50 values ranging from 46.81 to 68.10 μM, compounds 4 and 6 showed weak effects with the IC50 values of 96.57 and 79.46 μM, respectively, compared to that of the positive control compound, dexamethasone (IC50 14.20 μM).