FLUORIDE: AN EVALUATION AND EVIDENCE ON HUMAN DEVELOPMENTAL METABOLIC AND NEUROLOGICAL CHANGES - EPIDEMIOLOGICAL STUDY

Fluoride is widely present in our surroundings in a variety of forms and has the potential to adversely affect the biological environment and human health. For teeth and bones to remain healthy, uoride is essential. Although too much uoride might harm an animal's body, it is necessary for animals to grow and develop healthily. The majority of the state's groundwater is either salty or contains signicant levels of uoride and nitrates. The neurological system is primarily affected by uoride's harmful effects on the body. Numerous research conducted recently have demonstrated that uoride might be harmful to macrophages and other immune system components. The kidney, liver, and heart are the delicate tissues that are most vulnerable to uoride poisoning. Fluoride toxicity researchers have recently become interested in free radicals and oxidative stress. Cognitive decline, compromised neuronal and cerebrovascular integrity, and metabolic abnormalities are all examples of uoride's neurotoxicity. The toxicity of uoride large quantities of certain uoride salts can be harmful to the skin or eyes, and soluble uoride salts are toxic in large concentrations. Age range: 07–14 years old In comparison with the control participants, the uoride content in the serum was considerably (p<0.001) higher in the severe subjects (519%), moderate subjects (320%), and mild subjects (140%). Between the ages of 15 and 45, the blood uoride content was considerably (p<0.001) higher in the severe group (5172%), moderate group (268%), and mild group (165%). topics under control. Age range: 46–75 years old When compared to the control subjects, the severe subjects had signicantly (p<0.001) higher serum uoride concentrations (694%), followed by moderate subjects (432%) and mild subjects (240%).