Fixation of Carbon Dioxide Into 1,3‐Dicarbonyl Scaffolds: Synthesis of Insecticides and Stable Carboxylic Acid Derivatives

Excessive carbon dioxide emissions are a major cause of global warming and pose serious environmental risks. Consequently, converting carbon dioxide into high‐value‐added or widely applicable products has attracted widespread attention in recent decades, garnering extensive research. However, new and efficient carbon dioxide conversion pathways remain limited. Meanwhile, the global markets for pesticides and pharmaceutical precursors continue to expand, highlighting a strong demand for structurally versatile and synthetically accessible building blocks. Against this backdrop, after optimizing the reaction conditions, we successfully utilized carbon dioxide as a raw material to synthesize a series of insecticidal compounds. Based on this, we further expanded this strategy to broader application fields, providing a highly attractive avenue for sustainable carbon utilization. Through systematic substrate screening, 1,3‐cyclopentanedione and Meldrum’s acid—two scaffolds widely used in medicinal chemistry and materials science—were identified as excellent substrates and subsequently employed to synthesize two key precursors with high application potential. The resulting carboxylated products feature modular functional handles, high structural stability, and strong derivatization potential, rendering them promising platform precursors for the synthesis of diverse bioactive molecules and functional materials.