First Do No Harm? Modeling Risks and Benefits of Challenge Trials for Hepatitis C Vaccine Development
Alyssa Bilinski, Rachel Slimovitch, Andrew Mendlowitz, Jordan J Feld, Joshua A Salomon- Infectious Diseases
- Microbiology (medical)
Abstract
Background
In 2019, about 58 million individuals were chronically infected with hepatitis C virus. Some experts have proposed challenge trials for hepatitis C virus vaccine development.
Methods
We modeled incremental infections averted through a challenge approach, under varying assumptions regarding trial duration, number of candidates, and vaccine uptake. We computed the benefit-risk ratio of incremental benefits to risks for challenge versus traditional approaches. We also benchmarked against monetary costs of achieving incremental benefits through treatment.
Results
Our base case assumes 3 vaccine candidates, each with an 11% chance of success, corresponding to a 30% probability of successfully developing a vaccine. Given this probability, and assuming a 5-year difference in duration between challenge and traditional trials, a challenge approach would avert an expected 185 000 incremental infections with 20% steady-state uptake compared to a traditional approach and 832 000 with 90% uptake (quality-adjusted life-year benefit-risk ratio, 72 000 & 323 000). It would cost at least $92 million and $416 million, respectively, to obtain equivalent benefits through treatment. BRRs vary considerably across scenarios, depending on input assumptions.
Conclusions
Benefits of a challenge approach increase with more vaccine candidates, faster challenge trials, and greater uptake.