Outline
DOI: 10.17140/npoj.2025.v9.i01.pp01-06.2212 ISSN: 2380-0445
Fibroblast Growth Factor 23 as a Potential Target for Treatment
Fan Li, Zhousheng XiaoThis fibroblast growth factor-23 (FGF-23) has been found as a circulating hormone and pathogenic factor in many diseaseconditions. This review focuses on recent advances in FGF-23 as a therapeutic target, including fibroblast growth factor receptors(FGFR) tyrosine kinase inhibitor, FGF-23 antibody, FGF-23 C-terminal peptide, CYP24A1 inhibitor, and FGF-23 antagonist. Wealso update the advantages and disadvantages of targeting upstream and downstream molecules in FGF-23 signaling pathways.
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