DOI: 10.1097/ypg.0000000000000425 ISSN: 0955-8829
Female-specific associations of glyoxalase 1 polymorphisms with schizophrenia in a Han Chinese case–control study
Amy Jing-Wen Yin, Wei-Wei Wang, Wenge Zhang, Xudong Luo, Susu Xiong, Chen Yan, Kangdu Chen, Zhun Dai, Yusheng Zhao, Zhixiong Lin, Guoda Ma, Dong Lv
Background
Emerging evidence suggests that glyoxalase 1 (Glo-1) may contribute to sex-specific phenotypes in schizophrenia. This study aims to investigate the sex-specific effects of
Glo-1
polymorphisms on schizophrenia susceptibility.
Methods
Four
Glo-1
genetic polymorphisms were genotyped using SNaPshot technology in a sample of 1214 schizophrenic patients and 1138 age- and sex-matched healthy controls.
Results
Significant associations were found between schizophrenia and control groups in both genotypic [
P
= 0.044, false discovery rate (FDR) correction] and allelic (
P
= 0.036, FDR correction) distributions of the rs1781735 polymorphism, whereas no significant difference for rs9470916, rs4746, or rs1130534 (
P
> 0.05). Haplotype analysis for the rs9470916-rs1130534-rs4746-rs1781735 haplotype revealed significant associations with schizophrenia, particularly for the
C-T-A-G
haplotype, which was less frequent in schizophrenic patients than controls [odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75–0.98,
P
= 0.024]. In sex-stratified analyses, significant associations in females were observed for rs1781735 (
P
= 0.020 for genotype,
P
= 0.004 for allele, FDR correction), rs1130534 (
P
= 0.037 for genotype,
P
= 0.011 for allele, FDR correction), and rs9470916 (
P
= 0.020 for genotype,
P
= 0.004 for allele, FDR correction). Furthermore, haplotype analysis identified female-specific associations for the
C-T-A-G
(OR = 0.73, 95% CI = 0.59–0.91,
P
= 0.005) and
A-A-A-T
(OR = 1.38, 95% CI = 1.08–1.75,
P
= 0.009) haplotypes, whereas no associations were detected in the male subgroup.
Conclusions
Single-nucleotide polymorphisms in
Glo-1
exhibited a female-specific association with schizophrenia in a Han Chinese cohort, suggesting a potential sex-specific role of Glo-1 in schizophrenia susceptibility.