Fast and Sensitive Electrochemical Detection of Antiviral Drug Oseltamivir Based on Graphene/MXene Nanohybrid
Arman Khavand, Marjan Fallah, Fereshteh ChekinIntroduction:
Influenza virus belongs to the Orthomyxovirus family. This singlestranded RNA virus causes seasonal outbreaks with high morbidity and mortality. Oseltamivir (OST) is effective in the prevention and treatment of epidemic influenza. Hence, studying the electrochemical properties of OST is of interest.
Methods:
In this work, a low-cost graphene/MXene (Gr/MX) composite-modified carbon paste electrode (CPE) was used to detect OST. The Gr/MX was fabricated using the sonication method. The Gr/MX modified CPE detects OST well in phosphate buffer solution (PBS) at pH 7.0.
Results:
The electro-oxidation peak of the OST drug appeared at ~1.01 V. The wide linear sensing range (0.2-7.0 μM) and low detection limit (0.08 μM) with high sensitivity (28.26 μA μM-1 cm-2) for OST were determined by square-wave voltammetry. The results confirm that the synthesized novel Gr/MX nanohybrid exhibits excellent electrocatalytic activity towards OST with good selectivity, repeatability, reproducibility, and stability. The cost-effective Gr/MX/CPE sensor was successfully applied to measure OST in plasma and urine.
Discussion:
The synergistic enhancement to the detection of OST resulted from the large active surface area, high conductivity, and rapid electron transfer rate of Gr, which promoted electrocatalytic activity with the assistance of the MX nanostructure.
Conclusion:
The Gr/MX hybrid platform can be applied in clinical analysis laboratories and industry quality control for the determination of OST.