Facial-onset sensory and motor neuronopathy with myasthenia gravis: A case report
Chengyu Pan, Xiangrong Yang, Zhenzhen Tai, Zhiwei Zhou, Renfang Hao, Jin Wang, Tao Liang- General Medicine
Rationale:
Facial-onset sensory and motor neuronopathy (FOSMN) is a greatly rare disease, so far, autopsy evidence that is associated with neurodegenerative. Myasthenia gravis (MG) is an antibody-mediated and complement-involved acquired autoimmune disorder of the post-synaptic neuromuscular junction. There have been few reports about if there is related between the 2. In this study, we present the case of a man who was diagnosed as FOSMN with MG in continuity.
Patient concerns:
The patient chief complaints were right-side facial numbness and right-eyelid incomplete closure, followed by slurred speech and dysphagia, and the symptoms gradually progressed. The patient serum was positive for anti-AchR and anti-Titin antibodies.
Diagnoses:
The patient was diagnosed FOSMN with MG.
Interventions:
The patient symptoms were relieved after pyridostigmine bromide and prednisolone treatment.
Outcomes:
Symptoms have improved.
Lessons:
Facial-onset sensory and motor neuronopathy and MG have disparate clinical features. Therefore, we reported a rare case in which the 2 conditions concurrently existed. Immune dysfunction might be the pathogenesis of this association, while there is no definite evidence to support it, further studies are needed.