Extensive Mandibular Bone Regeneration Following Iodoform and Lyophilized Bone Grafting in a Patient Initially Indicated for Hemimandibulectomy

Mandibular cysts arise from various etiologies and generally exhibit benign characteristics, with favorable treatment outcomes. Nevertheless, extensive cystic lesions may involve cortical bone, leading to substantial bone loss, reduced mechanical integrity of the mandible, and an increased risk of pathological fractures. In severe cases, hemimandibulectomy may become a clinical option, potentially resulting in functional and aesthetic impairment and requiring complex mandibular reconstruction. Therefore, conservative regenerative strategies aimed at preserving mandibular continuity may provide substantial benefits for patient recovery and quality of life. In this case report, we present a successful approach in which a mandible severely affected by benign cyst‐induced bone loss was preserved and extensively regenerated over a 6‐year follow‐up period. Following preoperative endodontic management with iodoform, the cyst was completely enucleated, and the resulting extensive bone defect was filled with lyophilized bovine bone combined with iodoform and covered with collagen membranes and a titanium mesh. Long‐term radiographic follow‐up demonstrated progressive increases in radiopacity and integration of the treated area, whereas computed tomography at 5.5 years revealed restoration of cortical bone continuity and extensive mandibular remodeling. At 6 years, the treated region exhibited radiopacity similar to that of the contralateral preserved mandibular region. These findings suggest that, in carefully selected extensive benign mandibular lesions, a conservative regenerative approach may preserve mandibular continuity and potentially avoid extensive mandibular resection.