EXPRESS: FDG: Five Decades of Transforming Molecular Imaging and Still Illuminating the Brain

Over half a century after its introduction, [ ¹⁸ F]fluorodeoxyglucose ([ ¹⁸ F]FDG) remains a cornerstone of molecular imaging by positron emission tomography (PET). This commentary reflects on [ ¹⁸ F]FDG-PET’s transformative role in neuroscience, highlighting its fundamental contributions to understanding brain metabolism and supporting clinical diagnoses of brain disorders, and the continuing evolution and refinement of brain PET imaging.