Exploring the link between atopic dermatitis and lipid profiles in children: a cross-sectional analysis

Aim Atopic dermatitis is a chronic inflammatory skin disorder with multifactorial pathophysiology, including immune dysregulation, epidermal defects, and environmental triggers. Recent studies suggest an association between atopic dermatitis (AD) and dyslipidemia, driven by systemic inflammation, but this link remains unclear in pediatric populations. Methods A total of 52 children with AD and 55 healthy controls aged 6–17 were analyzed. Lipid profiles, including total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides, were compared between groups. Disease severity was assessed using the SCORing Atopic Dermatitis (SCORAD) index. Statistical analyses included t-tests, ANOVA, and chi-square test. Results No significant differences in BMI, age, or socioeconomic factors were observed between groups. AD patients showed slightly higher total cholesterol (4.22 vs. 3.99 mmol/L, <em>P</em> = .057) and low-density lipoprotein cholesterol (2.47 vs. 2.28 mmol/L, <em>P</em> = .097) compared to controls, though these differences did not reach statistical significance. Triglyceride and high-density lipoprotein cholesterol levels were comparable. Lipid levels did not correlate significantly with AD severity. Conclusion While trends suggest higher lipid levels in children with AD, no significant associations were identified. Variations across global studies highlight methodological and demographic differences.