DOI: 10.1039/d6ra05427g ISSN: 2046-2069
Exploring DHPM-azole hybrid molecules for antibacterial drug discovery: synthesis and biological assessment
Gobind Kumar, Safiyah Ghumran, Neha Manhas, Pule Seboletswe, Afsana Kajee, Asif Raza, Arun K. Sharma, Parvesh SinghMolecular hybridization of dihydropyrimidinones with 1,2,4-triazole and benzotriazole afforded potent antibacterial agents active against MRSA and other bacterial pathogens, with low cytotoxicity and promising in silico pharmacokinetic profiles.