DOI: 10.1039/d3cc03216g ISSN:
Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states
Aleksandra Kolodziejczyk, Laurence A. Nafie, Aleksandra Wajda, Agnieszka Kaczor- Materials Chemistry
- Metals and Alloys
- Surfaces, Coatings and Films
- General Chemistry
- Ceramics and Composites
- Electronic, Optical and Magnetic Materials
- Catalysis
We report enormous enhancement of ROA signal detected for mature amyloid fibrils and/or prefibrillar states of different proteins. ROA is observed at earlier stages of fibril formation than VCD and provides access to a broader range of vibrations.