Evidence Synthesis of Mobile-Based Smoking Cessation Interventions for Adult Non-Pregnant Smokers and Practice Recommendations Based on the Chinese Context

Introduction: Tobacco dependence is a leading preventable cause of death globally and in China. Traditional cessation services face low coverage, poor accessibility, and suboptimal adherence. Mobile health interventions—SMS and smartphone apps—offer scalable, personalized alternatives and have proven effective. However, translating evidence to China faces two bottlenecks: locally available apps lack efficacy validation in Chinese populations, and integration pathways with existing services remain undefined. This study synthesized best evidence on mobile-based smoking cessation interventions for adult non-pregnant smokers and formulated contextualized recommendations for China. Methods: Following evidence-based medicine methodologies, we systematically searched clinical decision support systems, Chinese and English databases, guideline websites, and professional association websites for literature published up to 31 August 2026. Literature quality was assessed using rigorous tools, and evidence was graded according to the Joanna Briggs Institute system. Results: 22 publications were included, comprising 2 clinical decision, 5 guidelines, 1 expert consensus, 12 systematic reviews, 1 statistical report, and 1 randomized controlled trial. A total of 28 best evidence items were synthesized. Conclusions: This study summarizes best evidence on role orientation, mechanisms, functionalities, and intervention strategies of mobile-based smoking cessation for adult non-pregnant smokers. The findings, combined with China-specific recommendations, provide valuable references for local development. Implications: Mobile cessation interventions should be integrated into routine care. In China, developers should prioritize WeChat-based platforms and culturally tailored features to address social pressures such as the ritual of “offering a cigarette.” A stratified delivery model is recommended: interactive apps for users under 40, and voice or SMS services for older adults.