DOI: 10.3390/v16030441 ISSN: 1999-4915

Evaluation of Vaccine Immunogenicity—Correlates to Real-World Protection: Influenza

Csaba Laszlofy, Gyorgy Fazekas, Zoltan Barath, Zoltan Vajo
  • Virology
  • Infectious Diseases

Recent events highlighted that, despite decades of studying vaccine immunogenicity and efforts toward finding correlates of protection, evaluating real-world vaccine efficacy as well as establishing meaningful licensing criteria still represents a significant challenge. In this paper, we review all aspects of influenza vaccine immunogenicity, including animal and human challenge studies, humoral and cellular immunity parameters, and their potential correlation with real-life protection from disease.

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