Evaluation of “Tumor Necrosis Factor-Alpha for Rheumatoid Arthritis Patients” in Karbala Population
Roaa Noori Ali, Orass Madhi ShaheedAbstract
Background:
Rheumatoid arthritis (RA) refers to a persistent disease characterized by inflammation and gradual deterioration of the joints. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine that plays a crucial role in controlling the inflammatory response in joint diseases such as RA and another autoimmune disease. TNF-α in particular plays a significant role in the pathogenesis of RA disease and is connected to inflammation of the joint.
Objectives:
The aim of this research was to evaluate the serum TNF-α in RA patients.
Materials and Methods:
“Case–control” study was performed to involve 150 subjects. The sample of serum was taken from three groups, the first group was the patients with early diagnosis RA, the second group were under treatment patients with RA, and healthy participants made up the third group. The serum of this sample used to identify TNF-α was assessed using the enzyme-linked immunosorbent assay technique.
Result:
Our analyses revealed the level of serum TNF-α in patients undergoing treatment for RA (12.31 ± 0.85) compared to the control group (11.89 ± 1.19) increased significantly (
Conclusion:
According to the results of the current study show, the patients with RA under treatment had significantly higher levels of the TNF-α in serum.