DOI: 10.4103/mjbl.mjbl_1163_23 ISSN: 1812-156X

Evaluation of Beta-2 Microglobulin, Epidermal Growth Factor in Gingival Crevicular Fluid during Removable Orthodontic Treatment in Adolescents and Adults

Riyadh Salih Hamzah, Nebrass Nasir-Alla Al-Dapagh, Wisam Wahab Sahib Alhamadi
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Abstract

Background:

Removable orthodontic appliances that the patient can remove for cleaning and that may be made to exert stresses on the teeth using springs, screws, and other mechanical parts.

Objectives:

The study’s objectives, therefore, include evaluating the immunological responses in the mouths of people with removable orthodontics devices.

Materials and Methods:

A total of (50) individuals including 30 (60%) patients and 20 (40%) controls, for those patients measured baseline T0, after the first month of activation, T1 was measured followed by T2 measurement after the second month of activation by gingival crevicular fluid (GCF).

Results:

The findings showed that the patient group had a statistically significant increase in epidermal growth factor (EGF) concentration compared to the control group ( P ≤ 0.05). The group increased in EGF conc. as opposed to the control group and its conc. Within the patient’s group, with T0 (baseline) being higher than T1 (after 1st month) and T1 being higher than T2 (after 2nd month) so EGF concentration decreased over time. On the other hand, the findings showed that the patient group also had a significant increase in β2-MG conc. As compared to the control group, its concentration in the patient group at T0 (baseline) was lower than T1 (after 1 month), and T1 was lower than T2 (after 2 months) so β2-MG concentration increased with time. The concentration of EGF and β2-MG was determined by ELISA methodology.

Conclusion:

In contrast to controls, patients had higher concentrations of EGF and 2-MG, and the prevalence of people wearing orthodontics was unexpectedly high.

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