EVALUATION OF ADVERSE DRUG REACTIONS IN THE PATIENTS SUFFERING FROM TUBERCULOSIS WITH HIV: A RETROSPECTIVE COHORT STUDY

TB is a communicable disease,become one of the leading infectious diseases that cause death after HIV. Side effects of the antituberculosis (anti-TB) drugs may be mild as well as serious. Non-adherence to treatment because of adverse drug reactions is one of the major problems in tuberculosis patients.Hence we aim to study the adverse drug reactions and causality assessment in cases receiving anti-TB drugs. An observational retrospective study was used in this study. Patients taken for the study that treated for tuberculosis in the district TB center in Wardha Civil Hospital.TB patients and TB with HIV-reported patients were included in this study while TB with additional illness- was excluded.2 years of data were collected. A majority of cases reported GIT problems followed by musculoskeletal and skin reactions. Data was scrutinized by using descriptive and inferential statistics using the Chi-square test,Kappa Test and the software used in the analysis were SPSS 27.0 version and Graph-Pad Prism 7.0 version. For the Causality assessment of ADR WHO-UMC was used.