Outline
DOI: 10.1039/d6ob01291d ISSN: 1477-0520
Evaluation of 3′,4′-cyclopropyl monomers for oligonucleotide therapeutic applications
Seetha Krishnamoorthy, Molly S. Blevins, Steven Chin, Yi-Ju Tseng, Jinsen Chen, Xiaoshuai Fan, Yongfeng Yang, Andrew Watkins, Jeff Cheng-Wei Lin, Aditi Dubey, Sumit Mahajan, Han Nguyen, Kayon Colao, Santhosh Kumar ThatikondaThis novel cyclopropyl modification acts as a conformational lock, tuning duplex stability and maximizing nuclease resistance against enzymatic degradation.
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