DOI: 10.1097/inf.0000000000005416 ISSN: 0891-3668
Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana
Melanie M. Dubois, Mackenzie Powell, Sara Schenkel, Samuel Kgole, Gosego Masasa, Martha Ngwaca, Boitshepo Phale, Nyaladzi C. Maphorisa, Terence Mohammed, Sikhulile Moyo, Tuduetso Molefi, Topo Makhondo, Lebalang Mosiane, Sidney O. Kololo, Tanvi Sharma, Heather Jaspan, Leslie A. Enane, Lisa M. Butler, Lucy Mupfumi, Paul Christos, Radhika Sundararajan, Jyoti Mathad, Daniel Fitzgerald, Kathleen PowisAbstract: This Botswana-based study evaluated the prevalence of tuberculosis (TB) infection and disease among 50 adolescents, including 25 HIV-exposed uninfected (HEU) and 25 HIV-unexposed uninfected. We found that 12% of adolescents HEU had a positive QuantiFERON-TB Gold Plus test, while no adolescent HIV-unexposed uninfected tested positive. This exploratory study found that adolescents HEU may be at increased risk for TB infection and disease, with larger studies needed.