Estimation of the Polymorphism of IL-1, IL-6, and IL-8 in Hyperlipidemia and Association with Type 2 Diabetes Mellitus
Anwer Th. Shehab, Orass M. ShaheedAbstract
Background:
Hyperlipidemia is a medical state considered via an abnormal elevation of lipids (such as cholesterol and triglycerides) in the bloodstream, resulting in impaired lipid metabolism. This condition is becoming increasingly prevalent worldwide.
Objectives:
Estimating the polymorphism of IL-1, IL-6, and IL-8 and determining the association of this polymorphism with type 2 diabetes mellitus.
Materials and Methods:
This study was conducted on 100 subjects were collected from 50 patients of hyperlipidemia with diabetes mellitus type 2 and another group of 50 healthy controls. Blood samples were collected from patients attending Wasit province from Al-Karama Hospital from the first of December 2021 to the end of February 2022, followed by genomic DNA extraction from fresh blood and detection of amplified products.
Results:
The results revealed that there was a high significance of fasting blood sugar, Chinese Hamster ovary, triglycerides, low-density lipoprotein, high-density lipoprotein, and very-low-density lipoprotein in the case group compared to the control group at
Conclusion:
The polymorphism of IL-1B single nucleotide polymorphism (SNP), IL-8 SNP, and IL-6 (G/C)-174 SNP is not significantly linked with the hazard of disease.