EP 065 Body Composition: A Crucial Factor in Downstaging and Postoperative Complications of Neoadjuvant Chemotherapy for Gastric Cancer
Zhuanmei Jin, Jianling Zhang, Wenzhen YuanAbstract
Objective
Postoperative complications may impair patients quality of life, potentially affecting their overall survival (OS). However, no significant difference in OS was observed among patients who received neoadjuvant chemotherapy (NAC), irrespective of complication occurrence. This study aims to investigate and elucidate the underlying mechanisms associated with this observation.
Methods
We conducted a retrospective analysis to collect the clinical data of patients with GC who underwent surgery after receiving NAC. Based on the presence of a post-NAC downstaging period and postoperative complications, we categorized the patients into four groups. First, we assessed the OS disparity between the groups. Subsequently, we performed a comparative analysis of the body composition and hematological indexes of patients from the four groups.
Results
We included 295 patients in the study: group A comprised 83 patients, group B comprised 32 patients, group C comprised 83 patients, and group D comprised 97 patients. Group A patients had the longest OS of 40.1 ± 20.53, whereas group C patients had the shortest OS of 32.15 ± 25.09. The skeletal mass index and skeletal mass area were highest in group A, lowest in group C, higher in group A than in group C (p < 0.05). With respect to hematological indexes, the prognostic nutritional index was highest in group A and lowest in group C. The PNI in group A was significantly higher than that in group C (p < 0.05).
Conclusion
Patients with advanced GC who experienced post-NAC downstaging and no postoperative complication had the longest OS.