Eosinophilic Granulomatosis with Polyangiitis (EGPA): A Case Report Presenting with Peripheral Polyneuropathy

Background: Eosinophilic granulomatosis with polyangiitis is a rare clinical condition with multiple organ involvement. We report a case of a 64-year-old male patient who presented with symptoms of chronic rhinosinusitis, numbness, and pain in both lower limbs, weight loss of 6 kg/3 months, and subcutaneous vasculitis lesions along the forearms and legs on both sides. The patient had peripheral eosinophilia with an eosinophil count of 11.6%, eosinophil count of 1.56G/l, positive pANCA test, and electromyography results showing damage to the left calf nerve, bilateral superficial peroneal nerve, and left deep peroneal nerve with axonal loss. Biopsy results of calf muscle showed chronic granulomatous vasculitis. The patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) according to the ACR/EULAR 2022 criteria. The patient was given intravenous Methylprednisolone, followed by maintenance treatment with reduced doses of Corticosteroids and Methotrexate. The patient’s leg pain was significantly reduced, numbness in both lower limbs was reduced, and the patient’s quality of life was improved. Methods: clinical case report. Results: The patient’s peripheral polyneuropathy and subcutaneous vasculitis were significantly reduced after treatment with Corticosteroids and Methotrexate. Conclusion: Eosinophilic granulomatosis with polyangiitis is a rare clinical condition with manifestations of multiple organ damage. Timely detection and diagnosis help increase treatment effectiveness and improve clinical symptoms for patients.