Enhancing Human Cognitive Performance Through Physical Activity: Effect of Moderate-to-Vigorous Physical Activity on Executive Function in Chinese Adolescents

Executive function (EF) is a core component of human cognitive performance. This study investigated whether increasing the duration of moderate-to-vigorous physical activity (MVPA) could enhance this critical cognitive ability in Chinese adolescents. Adolescents (13.4 ± 0.5 years) from two secondary schools in Jiangsu Province were recruited, screened, and individually randomized into an intervention group (n = 101) and a control group (n = 105); after three withdrawals, the final analytical sample comprised 98 and 105 participants, respectively. EF was compared using independent and paired sample t-tests, analysis of covariance (ANCOVA), and effect size tests. Post-intervention, adolescents in the intervention group showed a significantly longer daily MVPA duration than the control group (mean difference 25.16 min, p < 0.05). As an exploratory analysis, sex-stratified ANCOVAs were conducted. After adjusting for pre-intervention inhibition control reaction times (RTs), ANCOVA revealed that boys in the intervention group had a lower mean inhibition control RT (1.03 ms lower than controls, p < 0.05). With pre-intervention 2-back RTs as a covariate, ANCOVA indicated significant reductions in mean 2-back RTs for intervention group boys (191.09 ms lower, p < 0.05) and girls (175.62 ms lower, p < 0.05). After adjusting for pre-intervention cognitive flexibility RTs, boys in the intervention group also exhibited a significantly lower mean cognitive flexibility RT (102.7 ms lower, p < 0.05). In conclusion, a combined aerobic and resistance (HIIT) exercise intervention effectively increased adolescents’ physical activity time, and concurrent improvements were observed in key components of human cognitive performance—specifically inhibition control, working memory, and cognitive flexibility in boys and working memory in girls.