DOI: 10.1039/d6ra00750c ISSN: 2046-2069
Engineering iron oxide nanoparticles for enhanced radiosensitization
Indiana Ternad, Valentin Lecomte, Eglantine Beauchot, Camille Stassin, Anne-Catherine Heuskin, Thomas Vangijzegem, Sébastien Penninckx, Henri-François Renard, Sebastien Boutry, Carine Michiels, Dimitri Stanicki, Sophie LaurentEngineered iron oxide nanoparticles internalized by cancer cells and degraded in lysosomes induce thioredoxin reductase inhibition, leading to redox imbalance and enhanced radiation-induced DNA damage, thereby promoting radiosensitization.