Outline
DOI: 10.1039/d6cc05733k ISSN: 1359-7345
Engineering collismycin biosynthesis enables potent acetylcholinesterase inhibitors
Jiyuan Yang, Yanqing Li, Jingjing Li, Yanjun Song, Changli Sun, Hongxu Liu, Fanyu Dong, Runping Fang, Jianhua Ju, Weilong LiuBy integrating pathway engineering with chemical synthesis, we rapidly generated a library of collismycins and identified a nanomolar acetylcholinesterase inhibitor that outperforms the clinical drug galantamine.
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