DOI: 10.3390/ijms242316904 ISSN: 1422-0067
Energy Regulation in Inflammatory Sarcopenia by the Purinergic System
Miguel Marco-Bonilla, Maria Fresnadillo, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero- Inorganic Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Computer Science Applications
- Spectroscopy
- Molecular Biology
- General Medicine
- Catalysis
The purinergic system has a dual role: the maintenance of energy balance and signaling within cells. Adenosine and adenosine triphosphate (ATP) are essential for maintaining these functions. Sarcopenia is characterized by alterations in the control of energy and signaling in favor of catabolic pathways. This review details the association between the purinergic system and muscle and adipose tissue homeostasis, discussing recent findings in the involvement of purinergic receptors in muscle wasting and advances in the use of the purinergic system as a novel therapeutic target in the management of sarcopenia.