DOI: 10.1039/d6gc02989b ISSN: 1463-9262
Enantioselective total synthesis of colchicine using electrochemical and mechanochemical methods
S. M. Shakib Kazmi, Prabir Sarkar, Sigitas Stončius, Aleksander E. Rubtsov, Andrei V. MalkovAn eight-step enantioselective synthesis of (+)-colchicine combines mechanochemistry, electrochemistry and organocatalysis. Electricity replaces stoichiometric oxidants and transition metals, offering a resource-efficient route to a complex molecule.