Electrochemically‐driven Organocatalytic Enantioselective Oxidative Coupling of Tetrahydroisoquinolines and Acrylaldehyde

An electrochemically‐driven organocatalytic enantioselective oxidative coupling of tetrahydroisoquin‐olines and acrylaldehyde was developed. Various chiral C1‐alkenyl tetrahydroisoquinolines derivatives were obtained with 69‐86% yields and 93:7‐96:4 er. Notable features of this reaction include asymmetric organocatalysis (5.0 mol% β‐ICD as catalyst), electricity as the oxidant, air atmosphere, and undivided cell. This synthetic route offers straightforward access to various optically active C1‐substituted tetrahydroisoquinolines derivatives.