DOI: 10.1021/acs.oprd.6c00091 ISSN: 1083-6160
Electrochemical Synthesis of Renewable Pyridines via Oxidative Ring Expansion
Silja Hofmann, Astrid Kjær Steffensen, Alexandros Xanthopoulos, Anders Riisager, Helena Lundberg, Tobias AnknerAbstract
Herein, an electrochemical method for the synthesis of 3-hydroxypyridines from renewable furfurylamine is reported under galvanostatic conditions, with current densities up to 100 mA/cm2 in an undivided cell and aqueous electrolyte. The process delivers good to excellent yields of 3-hydroxypyridine and substituted analogues and is readily scalable, as demonstrated in syntheses of up to 100 g in both batch and flow processes.